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1996-03-09
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Document 0376
DOCN M9650376
TI IFN-gamma restores HIV- and non-HIV-specific cell mediated immune
response in vitro and its activity is neutralized by antibodies from
patients with AIDS.
DT 9605
AU De Francesco MA; Caruso A; Dima F; Cantalamessa A; Canaris AD; Folghera
S; Fiorentini S; Flamminio G; Licenziati S; Peroni L; Gao J; Garotta G;
Turano A; Insitute of Microbiology, University of Brescia, Italy.
SO Scand J Immunol. 1996 Jan;43(1):94-100. Unique Identifier : AIDSLINE
MED/96151207
AB The addition of IFN-gamma to cultures of peripheral blood mononuclear
cells (PBMCs) obtained from asymptomatic HIV-infected patients increased
cell proliferation in response to HIV envelope synthetic peptides (Env),
influenza A virus (VIRUS), and allogeneic lymphocytes (ALLO) but not to
phytohaemagglutinin (PHA) stimulation. F(Ab)2 fragments of IgG purified
from the sera of HIV-seropositive patients specifically interfered with
IFN-gamma-induced cell proliferation in response to recall antigens.
Neutralization of the lymphokine activity was found to be sustained by
specific IFN-gamma antibodies. Data obtained demonstrate that IFN-gamma
can restore the cell-mediated immunity of a number of asymptomatic HIV+
individuals in vitro, while IFN-gamma antibodies present in sera of
patients with AIDS interfere with the activity of the lymphokine.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Amino Acid Sequence
Antibodies, Monoclonal/*IMMUNOLOGY Human HIV Antibodies/IMMUNOLOGY
HIV Envelope Protein gp120/PHARMACOLOGY HIV Infections/*IMMUNOLOGY HIV
Seronegativity/*IMMUNOLOGY IgG/IMMUNOLOGY Immunity, Cellular
Immunoglobulins, Fab/IMMUNOLOGY Interferon Type II/*IMMUNOLOGY
Interferon-gamma, Recombinant/IMMUNOLOGY Isoantigens/IMMUNOLOGY
Lymphocyte Transformation/DRUG EFFECTS/IMMUNOLOGY Molecular Sequence
Data Orthomyxovirus Type A, Human/IMMUNOLOGY Peptide
Fragments/PHARMACOLOGY Support, Non-U.S. Gov't
T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).